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A recent study, however, indicates that non-drowsy allergy medicine doesn’t hold true; the best allergy medicine and newer-generation antihistamines tested caused daytime drowsiness, too.
Results of the study, “Assessment of the Effects of Antihistamine Drugs on Mood, Sleep Quality, Sleepiness, and Dream Anxiety,” were published in the International Journal of Psychiatry in Clinical Practice. Ninety-two patients with chronic allergies were administered standard therapeutic doses of newer generation antihistamines, including cetirizine (Zyrtec), levocetirizine (Xyzal), and desloratadine (Clarinex), or older drugs, including hydroxyzine (Atarax) and pheniramine (Avil).
Histamines cause the stuffy nose; itchy, watery eyes; and rashy skin that are the hallmarks of an allergic reaction.
However, high doses can still induce drowsiness through acting on the central nervous system.These were some of the first antihistamines scientists developed. They also work in the part of the brain that controls . One of the most common side effects of first-generation antihistamines is feeling sleepy.